Antonio(s) is a Greek, Italian, Portuguese, Croatian, and Spanish first name. In the English language is translated as Anthony, and has some female derivates: Antonia, Antonietta, Antonella, Antónia, Antonieta, Antonieta, Antonia. It has also some male derivates such as: Antonis, Antoñito, Antonino, Antonello, Tonio, Toño, Toñín, Tonino, Nantonio, Totò, Tó or Toni. The Portuguese equivalent is António or Antônio. In old Portuguese the form Antão was also used. The Greek version of the name is Antonios.

The name derives from Antonius, a well known Latin family name, probably of Etruscan origin. Antonius has been said to derive from the Ancient Greek God "Adonis". This, however, is quite unlikely, since the Greek letter "δ" (delta) is equivalent to the Latin letter "d" and there is no recorded transformation of "δ" or "d" to "nt". The roman general Marcus Antonius held that the origin of the name was Anthon, son of Hercules. This myth, recorded by Plutarch, was probably created by Marcus Antonius himself, in order to claim divine parentage. The name was spread around European countries and languages because of Saint Antonios. Later, at the era of colonization, it was spread all around the world due to introduction to Christianity of the invaded indigenous populations (i.g. Americas, Africa, Asia)

The name is widely used in Italy, in Portugal and in Spain. After the Iberic peoples discovered the new world, many of them settled in the area, and, as a consequence, Antonio is one of the most popular first names in Latin America, as well as among Hispanics, and, to a small degree, North Americans in the United States.